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Even though the human brain weighs less than 2% of the body mass, it is the organ that consumes the most oxygen and therefore, it is more susceptible to oxidative stress (Sies et al., 2017)

The Polygonaceae plant has been widely used in China for more than one thousand years [237]

GLP-1R agonists modulate enteric immune responses through the intestinal intraepithelial lymphocyte GLP-1R

Clinically, this points to a bi-directional interaction between gut inflammation and brain inflammation, with mast cells acting as key transducers in both arenas 24